Effervescent tablets are an interesting form of solid products that offer some unique advantages over regular tablets. However, the manufacturing process involves some critical steps that need to be taken with care in the formulation and construction of the manufacturing facility.
Effervescents tablets VS other forms of supplements
Solid products for oral use remain the most common method of taking medication, although it has some drawbacks compared to other methods. One disadvantage is the risk of slow absorption of the active ingredient, which can be prevented by administering the drug in liquid form and thus allowing a lower dose to be used. However, since many active ingredients show limited stability in liquid form, effervescent tablets, which are dissolved in water prior to administration, have been formulated as an alternative dosage form.
The advantages of effervescent tablets over other oral forms include the ability to improve the taste, less irritating effect on the stomach, a less aggressive method of serving, and the consumer convenience of taking an effervescent tablet. The disadvantages of effervescent products are the need for a larger tablet size, a complicated production process and often the need to use special packaging materials.
Basics about effervescent products
Effervescent products consist of a soluble metallic acid and an alkali metal carbonate salt, one of which is often the active ingredient. Carbon dioxide is formed when this mixture comes into contact with water. The manufacture of effervescent tablets requires a conventional solid product manufacturing process that has been adapted to include some additional functions due to product characteristics.
Effervescent tablets manufacturing
The manufacture of effervescent tablets is similar in many ways to that of conventional granules or tablets, although due to the hygroscopicity and potential onset of the effervescence reaction in the presence of water, environmental control of relative humidity and water levels is of major importance during manufacture.
A maximum of 25 % relative humidity or less is sufficient to avoid problems of atmospheric moisture. Moderate to cool temperatures (25 ºC) in the manufacturing areas are also essential to prevent the granulations or tablets from sticking to the machinery and from picking up moisture from the air, which may cause product instability.
The equipment used in the manufacture of effervescent tablets are also the same as that for conventional tablets; the only difference is that it uses the rotatory press with special adaptations for compression.
In-process quality control is of major importance for these formulations as are stability testing and stress testing of packaging. Tablet disintegration and dissolution are of prime importance, and disintegration should be carried out using representative conditions. Hardness and friability are also important as these large tablets tend to chip easily.
UNIPRO production line
UNIPRO is European Effervescent tablets manufacturer for private label. We offer different ready-made effervescent tablets formulas that can be manufactured and packed in tubes for your Brand. We can also manufacture your custom formulas of effervescent tablets.
We are also local leader in electrolytes production in such form.
Our tablets are made in Europe in accordance with highest quality Standards in GMP Compliance factory.